The Power of Polynucleotides
How Polynucleotides Work – The Science, Made Simple
Think of polynucleotides as a gentle messenger for your skin cells, encouraging them to rest, recover, and rejuvenate.
They’re made from naturally occurring molecules (the same building blocks that make up DNA) and when introduced just beneath the skin, they work in harmony with your body’s own repair systems.
Why we Choose Plinest® by Mastelli
Pllinest® by Mastelli embodies a gentle yet powerful journey toward radiant, healthy skin- backed by decades of scientific dedication. With over 70 years of research and development driving Mastelli’s advancement in polynucleotide science, Plinest® stands out as a deeply refined, thoughtfully crafted solution.
What truly inspires me as a passionate nurse is that Plinest® isn’t just another filler- it’s a nurturing friend to your skin, made possible through Mastelli’s PN‑HPT® High‑Purification Technology. This high‑purity process delivers only the cleanest, most compatible polynucleotides, ensuring you experience a treatment that’s natural, safe, and effective.
Your Skin, Recharged
Polynucleotides (PNs) are bio-stimulating injectables that harness natural DNA fragments to:
01 \ Stimulate cell renewal & repair
02 \ Improve skin elasticity & hydration
03 \ Reduce fine lines & crepiness
04 \ Calm inflammation and redness
05 \ Restore tired, stressed skin from the inside out
Unlike dermal fillers, polynucleotides don’t add volume. Instead, they work at a cellular level — awakening your skin’s natural ability to heal and rejuvenate.
Treatment
Polynucleotides can be used across multiple areas to restore skin health and radiance. At MedSpa, we commonly treat the face for overall skin quality, the under-eye area to soften dark circles and fine lines, the neck and décolletage to improve texture and firmness, and the hands to rejuvenate delicate, aging skin. Each treatment plan is tailored to your individual needs, creating natural, regenerative results wherever your skin needs a boost.
The Benefits.
Improves skin elasticity
Restores hydration + glow
Reduces inflammation + oxidative stress
Your MedSpa Journey
01 \ Consultation — a detailed skin assessment to understand your needs
02 \ Treatment — a course of tiny, precise injections to stimulate regeneration
03 \ Glow — results build over weeks, with skin looking firmer, smoother, and more radiant
Frequently asked questions.
How many treatments will I need?
Most clients see best results with 2–3 sessions spaced a few weeks apart, followed by maintenance every 6–12 months.
When will I see results?
Skin quality starts improving after the first session, with full results developing gradually over a few months as collagen production increases.
Is there downtime?
Minimal downtime — you may see mild redness or swelling for 24–48 hours, but most clients return to normal activities straight away.
Are Polynucleotides safe?
Yes, they are highly purified, biocompatible, and have a strong safety profile, used in medical treatments for decades.
How long do results last?
With a full course, results typically last 6–12 months, with maintenance recommended.
Can I combine this with other treatments?
Yes — polynucleotides pair beautifully with treatments like skinboosters, laser, and dermal fillers for a holistic approach to skin health.
Begin your Renewal
At MedSpa, polynucleotides are more than a skin treatment- they’re a mindful act of renewal.
Your skin, reawakened. Your face, illuminated.
Socials